true. single. molecule. sequencing.

Quantitative RNA & Specialty DNA Sequencing Solutions

Contact

(781) 460-6016

Orders@seqll.com

Suite 210
317 New Boston St.
Woburn, Ma 01801

Our Belief

Science is our passion, Customer Service is our priority

We believe that cutting edge research shouldn’t begin with a copy.

Our mission is to enable research breakthroughs by helping customers harness the power of True Single Molecule Sequencing. Our sequencing services, sequencing equipment and bioinformatics are backed by unsurpassed customer support and uncompromising quality.

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True Single Molecule Sequencing, tSMS

tSMS enables direct parallel sequencing of millions of individual molecules. Find out how it can address common limitations of standard sequencing technologies for quantitative RNA & specialty DNA sequencing needs.

02.

Quantitative RNA Sequencing

Analyzing the differential expression of genes is a key goal of molecular biology. Find out how tSMS provides the most accurate RNA quantification available today.
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03.

Specialty DNA Sequencing

Find out how tSMS is ideally suited for challenging applications where precision is paramount, quantification is needed, sample quantity is small or samples are fragmented or degraded.
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tSMS

True Single Molecule Sequencing

tSMS detects millions of individual nucleotide incorporation events on single strands of DNA or RNA. Each event is labeled, imaged and then collated to produce a highly accurate sequence.

SeqLL’s True Single Molecule Sequencing technology requires no library prep or amplification. This reduces errors, eliminates sources of bias and improves turn-around time.

tSMS can accurately analyze minute quantities of substrate because its technology works on a molecular level. That means that even picogram-level samples can provide valuable data.

Our technology works on short fragments, as low as 50 base pairs. This enables the study of short genetic material or fragmented samples. Other common sequencing techniques require ~500 base pairs.

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services

Quantitative RNA Sequencing

Precise quantification of RNA transcripts is challenging with standard sequencing technologies as they require an amplification step. Rather than counting transcripts, these methods count copies. Since different transcripts have different amplification rates, copy counts can be distorted. SeqLL’s True Single Molecule Sequencing technology does not require amplification, so it can provide a highly accurate count of transcripts and detection of small fold changes.

Also, now available is SeqLL’s proprietary Direct RNA Sequencing technology sequencing without conversion to cDNA.

DNA Sequencing

SeqLL offers a range of specialty DNA sequencing services to address your toughest challenges. With True Single Molecule Sequencing of DNA, there are fewer steps in the sequencing process, resulting in more accurate data.

Accurate Quantification

Sensitive To Small Fold Changes

Rare Transcripts Captured

No Amplification Bias

Direct RNA Sequencing

Fewer opportunities to introduce errors

Improved signal-to-noise ratio.

Minimal erosion of sample volume, allowing for analysis of ultra-small quantity samples.

Bioinformatics

Maximizing the value of your experiment requires the conversion of high quality sequence data into novel biological insights through careful design & execution of an appropriate bioinformatics analysis approach.

Basic

Our specialists are available to work with your team from the initiation of your sequencing project to identify the appropriate type & scope of bioinformatics analysis required to meet the goals of your project.

Advanced

Our experienced bioinformatics team choose from a wide range of standard and advanced analytical methods to maximize the value of your data set and generate biologically meaningful insights to take your research to the next level.

Custom

For more complex bioinformatics needs, such as functional gene information mining or comparable genomic analysis, our team can work with you to create a custom bioinformatics package tailored to your specific needs

Testimonials

Sequencing Services

  • After experiencing the breadth & depth of coverage from the tSMS RNA-Seq technology, it became clear that these data will progressively replace microarray-based profiling. In our human blood profiling studies, we’re getting 10 times the information, at digital precision, for a similar cost by utilizing SeqLL’s services.

    Tim McCaffrey, PhD Director, Division of Genomic Medicine, The George Washington University Medical Center
  • Thank you, SeqLL, for continuing your outstanding support of our research by providing the best in sequencing services. As our recent publications attest, we have found that no other technology can match tSMS for high quality, publishable RNAseq findings. In addition, we appreciate the attention to detail and responsiveness that your organization provides.

    Georges St. Laurent III Former Scientific Director, St. Laurent Institute

Kind Words From Our Clients

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What your sequence is missing

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