true. single. molecule. sequencing.

RNA & DNA Sequencing Solutions


(781) 460-6016

Suite 210
317 New Boston St.
Woburn, Ma 01801


Our Belief

Science is our passion, Customer Service is our priority

We believe that cutting edge research shouldn’t begin with a copy.

Our mission is to enable research breakthroughs by helping customers harness the power of True Single Molecule Sequencing. Our sequencing services, sequencing equipment and bioinformatics are backed by unsurpassed customer support and uncompromising quality.


True Single Molecule Sequencing, tSMS

tSMS enables direct parallel sequencing of millions of individual molecules. Find out how it can address common limitations of standard sequencing technologies for quantitative RNA & specialty DNA sequencing needs.


RNA Sequencing

Analyzing the differential expression of genes is a key goal of molecular biology. Find out how tSMS provides the most accurate RNA quantification available today.


DNA Sequencing

Find out how tSMS is ideally suited for challenging applications where precision is paramount, quantification is needed, sample quantity is small or samples are fragmented or degraded.


True Single Molecule Sequencing

tSMS detects millions of individual nucleotide incorporation events on single strands of DNA or RNA. Each event is labeled, imaged and then collated to produce a highly accurate sequence.

SeqLL’s True Single Molecule Sequencing technology requires no library prep or amplification. This reduces errors, eliminates sources of bias and improves turn-around time.

tSMS can accurately analyze minute quantities of substrate because its technology works on a molecular level. That means that even picogram-level samples can provide valuable data.

Our technology works on short fragments, as low as 50 base pairs. This enables the study of short genetic material or fragmented samples. Other common sequencing techniques require ~500 base pairs.



Sequencing Services

  • After experiencing the breadth & depth of coverage from the tSMS RNA-Seq technology, it became clear that these data will progressively replace microarray-based profiling. In our human blood profiling studies, we’re getting 10 times the information, at digital precision, for a similar cost by utilizing SeqLL’s services.

    Tim McCaffrey, PhD Director, Division of Genomic Medicine, The George Washington University Medical Center
  • Thank you, SeqLL, for continuing your outstanding support of our research by providing the best in sequencing services. As our recent publications attest, we have found that no other technology can match tSMS for high quality, publishable RNAseq findings. In addition, we appreciate the attention to detail and responsiveness that your organization provides.

    Georges St. Laurent III Former Scientific Director, St. Laurent Institute

Kind Words From Our Clients


What your sequencing is missing




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Billerica, MA 01821

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