SeqLL provides leading‐edge RNA and DNA sequencing services and instruments. Our exclusive True Single Molecule Sequencing technology enables direct sequencing of millions of individual molecules. It does not involve PCR amplification at any stage of the process and offers simple, straight-forward Sample Prep protocols. It precisely reflects sample composition, without bias and loss of diversity & rare species.
True Single Molecule Sequencing is ideally suited for challenging applications, including low quantity, difficult or degraded samples such as cell‐free DNA, FFPE‐isolated nucleic acids, ancient DNA and forensic samples. Longer sequences are accurately assembled following shotgun sequencing using our powerful alignment software.
The tSMS platform offers maximum flexibility and avoids many of the challenges common for standard sequencing approaches. Our experienced team will work with you to develop innovative solutions tailored to the needs of each specific project.
True Single Molecule Sequencing is ideally suited for challenging applications where precision is paramount, quantification is needed, sample quantity is small or samples are fragmented or degraded.
amplification based sequencing of cancer transcriptions
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Lack of Amplification Biases Promises Highest Accuracy, Early in Pregnancy
SeqLL provides both sequencing services as well as instruments & reagents.
For customers who want to sequence in their own labs, preparing genetic material for the sequencing process is greatly simplified versus standard sequencing approaches.
tSMS Sample Prep is more streamlined in comparison with standard Library Construction approaches, reducing the hands-on time as well as turnaround time (TAT).
Both Direct RNA Sequencing (DRS) and DNA Sequencing have 1-3 step Sample Prep protocols which do not involve PCR at any stage, thus avoiding the sample bias and loss of diversity inevitable during PCR.
This makes tSMS the most advantageous approach for the many applications.
Direct RNA Sequencing is an important step forward in the RNA Sequencing world. For the first time, researchers can explore the RNA transciptome directly as it exists in vivo, with no conversion to cDNA or amplification required. DRS captures polyadenylated RNA directly without conversion to cDNA. Sequence RNA directly from the flow cell surface.